Mock Willett Lab Research

Department of Bioengineering

The Willett Lab

Musculoskeletal Regenerative and Rehabilitation Engineering

Current Research Projects

We focus on materials discovery and biofabrication with a particular interest in advancing next generation microphysiological systems (MPS), assembloids and organoids for tissue engineering and disease modelling.  

Organoids

Joints

  • Inflammatory cartilage spheroid models for study of Osteoarthritis disease progression
  • Cartilage-Synovial Fluid model for screening of injectable therapies
  • Performance organoids for study of mechanical loading on cartilage health and disease
  • Hormonally tunable cartilage spheroids for study of joint regeneration

Hematological

  • Biofabricated Bone Marrow models for study of stem cell therapeutics for blood cancers

Neural

  • Neural tract Glioblastoma models for study of brain cancer invasion

 

Implantable biomaterials
  • Hydrogel spheroids for Integrative cartilage repair
  • Oxygen controlling hydrogels for enhanced stem cell survival
  • 3D-bioassembly of clinically relevant orthopaedic replacement grafts

 

Bioinks
  • Hydrogels for volumetric additive manufacturing
  • Machine learning processes for Enhancing shape fidelity of volumetric additive manufacturing

Featured Publications

a gray background with yellow and blue spheres, in a box-like container. spheres contain bubbles, or cells.

2026

Spatial Patterning of Modular Gelatin-Peroxide Microspheres in Melt-Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials

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figure from 3D-Bioassembly of VH-Spheroids for Cartilage Regeneration: in Vitro Evaluation of Chondrogenesis, Fusion and Lateral Integration

2022

3D-Bioassembly of VH-Spheroids for Cartilage Regeneration: in Vitro Evaluation of Chondrogenesis, Fusion and Lateral Integration

Advanced Materials Interfaces

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two white spheres in a gray grid

2021

Probing Multicellular Tissue Fusion of Cocultured Spheroids - A 3D-Bioassembly Model

Advanced Science

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The Willett Lab 

In 2022, the Willett lab relocated to the University of Oregon's Phil and Penny Knight Campus for Accelerating Scientific Impact. The Willett Lab is situated within the Department of Bioengineering in Eugene, Oregon, where its research centers on musculoskeletal regenerative and rehabilitation engineering.