Mock Plesa Lab Resources

Full source, installation instructions and usage examples are on Github.

• DAQmx compatible PCIe DAQ with at least 5 analog inputs, 2 digital outputs, and one hardware counter
• Intan Recorder (or similar recorder with ability to pass out data channel to analog out with minimal delay)
• Computer with relevant software
• Pulse generator (optional, only needed if using PhaSER to trigger a pulse train)

• LabVIEW2017 or later
• MATLAB 7.2 or later 

• PhaSER is very flexible! Get creative! 
• You just need a signal with an oscillation (silicon probe, twisted wire, sound wave)
• And something to trigger (light source, electrical stimulator, auditory tone generator)
• Accuracy of PhaSER will be partially influenced by the delay introduced when the data is read from your DAQ.

PhaSER's validation and its application to studying seizure susceptibility.

Read the preprint →

Further technical details on how PhaSER works.

Read the preprint →

An Open Box Science webinar on PhaSER and its uses.

Watch the webinar →

• christensonwicklab@gmail.com
• tristanshumanlab@gmail.com

Open an issue on the Github repository.

• Christenson Wick Z*, Philipsberg PA*, Kohler C, Lamsifer SI, Katanov E, Adam CD, Gordon KE, Feng Y, Vetere LM, Donnelly GC, Humphrey C, Cai DJ, Shuman T (2025) Interneuron theta phase locking controls seizure susceptibility. bioRxiv. https://www.biorxiv.org/content/10.1101/2025.09.10.675457v1.

• Vetere LM, Galas AM, Vaughan N, Kohler C, Feng Y, Christenson Wick Z, Philipsberg PA, Liobimova O, Gordon KE, Fernandez-Ruiz A, Cai DJ, Shuman T (2026) Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology. Cell Reports. https://doi.org/10.1016/j.celrep.2026.117646. PMID: 42441402.
• Feng Y, Diego KS, Dong Z, Christenson Wick Z, Page-Harley L, Page-Harley V, Schnipper J, Lamsifer SI, Pennington ZT, Vetere LM, Philipsberg PA, Soler I, Jurkowski A, Rosado CJ, Khan NN, Cai DJ, Shuman T (2025) Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy. Cell Reports. https://doi.org/10.1016/j.celrep.2024.115131. PMID: 39847482.
• Zaki Y, Pennington ZT, Morales-Rodriguez D, Francisco TR, LaBanca AR, Dong Z, Lamsifer S, Carrillo Segura S, Chen HT, Christenson Wick Z, Silva AJ, van der Meer M, Shuman T, Fenton A, Rajan K, Cai DJ (2025) Offline ensemble co-reactivation links memories across days. Nature. https://doi.org/10.1038/s41586-024-08168-4. PMID: 39506117.
• Pennington ZT, LaBanca AR, Sompolpong P, Abdel-Raheim SD, Ko B, Christenson Wick Z, Feng Y, Dong Z, Francisco TR, Bacon ME, Chen L, Fulton SL, Maze I, Shuman T, Cai DJ (2024) Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior. Cell Reports. https://doi.org/10.1016/j.celrep.2024.114871. PMID: 39427320.
• Chen L, Christenson Wick Z, Vetere LM, Vaughan N, Jurkowski A, Galas A, Diego KS, Philipsberg PA, Soler I, Feng Y, Cai DJ, Shuman T (2023) Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology. Journal of Neuroscience. https://doi.org/10.1523/JNeurosci.1204-23.2023. PMID: 37714705.
• Philipsberg PA, Christenson Wick Z, Diego KS, Vaughan N, Galas A, Jurkowski A, Feng Y, Vetere LM, Chen L, Soler I, Cai DJ, Shuman T (2023) Chronotate: An open-source tool for manual timestamping and quantification of animal behavior. Neuroscience Letters. https://doi.org/10.1016/j.neulet.2023.137461. PMID: 37619698. Github: https://github.com/ShumanLab/Chronotate
• Christenson Wick Z, Shuman T (2021) To stop the seizure, you must become the seizure: Closed loop stimulation phase locked to seizure waves disrupts kindled seizures while open loop stimulation fails. Epilepsy Currents. https://doi.org/10.1177/15357597211014187. PMID: 34690571, PMCID: PMC8512909.
• Nietz A, Krook-Magnuson C, Gutierrez H, Klein J, Sauve C, Hoff I, Christenson Wick Z, Krook-Magnuson E (2020) Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype. Journal of Neurophysiology. https://doi.org/10.1152/jn.00100.2020. PMID: 32902350, PMCID: PMC7717165.
• Christenson Wick Z, Tetzlaff M, Krook-Magnuson E (2019) Novel long-range inhibitory nNOS-expressing hippocampal cells. eLife. https://doi.org/10.7554/eLife.46816. PMID: 31609204, PMCID: PMC6839902.
• Christenson Wick Z, Krook-Magnuson E (2019) Seizing sequencing data to consider cell and circuit complexity. Epilepsy Currents. https://doi.org/10.1177/1535759719835658. PMID: 30955433, PMCID: PMC6610407.Christenson Wick Z, Krook-Magnuson E (2018) Specificity, versatility, and continual development: The power of optogenetics for epilepsy research. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2018.00151. PMID: 29962936, PMCID: PMC6010559.
• Christenson Wick Z, Leintz CH, Xamonthiene C, Huang B, Krook-Magnuson E (2017) Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24011. PMID: 28151564, PMCID: PMC5540851.